On Tuesday, the Bills placed Jones on the non-football/illness reserve and Moats on the injured reserve.
Jones has been bothered by a recurring calf injury, which has held him out two of the past three games, while Moats sustained an ankle injury in the Bills' blowout loss to the Seattle Seahawks this past Sunday.
In his third season with Buffalo, Jones finished with 41 receptions for 443 yards and four touchdowns, all career-highs.
Moats had played in each of Buffalo's first 14 games, registering 25 tackles in 2012.
To fill the empty roster spots, the Bills promoted wide receiver Chris Hogan and linebacker Greg Lloyd from their practice squad.