McCoy suffered the concussion in the fourth quarter of the Eagles' 31-6 loss against the Redskins on Nov. 18.
The fourth-year Pittsburgh product has garnered 750 yards and two touchdowns on the ground this year.
"McCoy will start," Eagles coach Andy Reid confirmed during Wednesday's practice. "He'll rotate in with Bryce (Brown)."
The rookie Brown started for McCoy over the last four contests and ran for 347 yards and four touchdowns over the first two games, but tallied just 40 yards rushing over the next two tilts. He fumbled four times over those four games.
