Kelly Olynyk added 15 points for Gonzaga (26-2, 13-0 West Coast), which is riding its best ranking in the poll ever.
Brandon Clark led Santa Clara (19-9, 7-6) with 14 points. Leading scorer Kevin Foster was saddled with three fouls in the first half and finished with just four points, 14 below his average.
Gonzaga needs one more victory to claim at least a share of the WCC regular season title it lost last season.
