A semi tractor trailer loaded with scrap metal overturned on state Route 12, near Pecan Street Southwest Tuesday afternoon, according to State Patrol Trooper Guy Gill.
Four cars and the semi were involved. Two people were taken to the hospital with serious injuries, one by air, Gill said.
Troopers were still investigating what caused the crash just after 4 p.m., in which they said the semi heading eastbound on the highway hit a Jeep Cherokee, also eastbound, as it was in a left turn lane.
That pushed the jeep into the westbound lane, hitting a Ford Ranger pickup, which was then rear-ended by a Saturn Ion.
A juvenile passenger of the Jeep was taken to Harborview Medical Center, and a 51-year-old Rochester man driving the pickup was taken to St. Peter's Hospital.
Both were expected to survive, Gill said.
The 62-year-old driver of the semi was not injured, the State Patrol said.
Troopers said no drugs or alcohol were involved.
Gill said about 6:45 p.m. that the roadway had been cleared.