Julius Randle scored 22 points en route to another double-double that led the Wildcats (2-0) to a blowout of the overmatched Norse (0-2).
Two days after the 6-foot-9, 250-pound forward debuted with 23 points and 15 rebounds for Kentucky, he scored 20 points in 28 minutes.
No. 21 Notre Dame 80, Stetson 49
Jerian Grant and Garrick Sherman scored 15 points each and the Irish (2-0) won for the second game in three days.
Pat Connauhgton added 10 points for Notre Dame, while Sherman led the team with nine rebounds. Senior point guard Eric Atkins finished with eight points, leaving him five short of 1,000 for his career.
Reserve Brian Pegg led the Hatters (0-2) with 13 points and Willie Green added eight points and nine rebounds.