Shoni Schimmel scored a career-high 33 points, leading a comeback that swept Louisville to an 85-75 win over No. 2-seed Xavier on its home court in Cincinnati.
The Cardinals (22-12) go to Spokane to play Gonzaga in a regional semifinal Saturday.
Second-seeded Xavier (29-3) had no answer for Schimmel, who rallied the seventh-seeded Cardinals from a seven-point deficit with six minutes to go. It was a stunning collapse by Xavier, which made it to the Elite Eight last season and had won 19 in a row.
Amber Harris led Xavier with 20 points, and the Musketeers made a season-high 14 3-pointers.
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Tiffany Hayes scored 23 points, Maya Moore added 16 and No. 1 Connecticut (33-1) beat ninth-seeded Purdue, 64-40, in Storrs, Conn. … Sugar Rodgers scored a career-high 34 points to lead fifth-seeded Georgetown (24-10) past fourth-seed Maryland, 79-57, in College Park, Md.
Danielle Robinson scored six straight points to break a tie, and Whitney Hand had a career-high 27 points as sixth-seeded Oklahoma (23-11) held on to beat third-seeded Miami, 88-83, in Charlottesville, Va.
Danielle Adams had 28 points and 11 rebounds, and second-seed Texas A&M (29-5) beat No. 7 Rutgers, 70-48, in Bossier City, La. … Adrian Ritchie scored 20 points off the bench to lead fifth-seed Wisconsin-Green Bay (34-1) past No. 4 Michigan State, 65-56, in Wichita, Kan. … Jasmine James’ put-back and free throw with 2.1 seconds left lifted No. 6 Georgia (23-10) to a 61-59 win over No. 3 Florida State in Auburn, Ala. … Brittney Griner had 30 points as top-seeded Baylor beat No. 9 West Virginia, 82-68, in Waco, Texas.