Amy Schumer Says She Had a ‘Botched' Medical Procedure as She Shows off 50-Lb Weight Loss
Amy Schumer is opening up about a medical procedure that seems to have gone wrong.
The actress and comedian, 44, who transitioned from stand-up standout to Comedy Central fame with her beloved series, Inside Amy Schumer, went on to film roles in projects like Trainwreck and I Feel Pretty. But in a recent live podcast appearance, the star made a subtle reference to a botched medical procedure.
"I feel happier than I've ever been before," Schumer told host Amanda Hirsch during a Dear Media by Night event featuring the "Not Skinny But Not Fat" podcast, for which she served as the surprise guest. "I actually had, kind of, a botched colonoscopy, so I'm not feeling very sexual."
While the crowd laughed at the moment, Schumer didn't offer too many further details.
Despite Schumer's jokes, a colonoscopy is an important examination of the inside of your large intestine that's helpful for diagnosing gastrointestinal diseases, such as inflammatory bowel disease and colon cancer. It can also help treat and prevent colon cancer. Healthcare providers recommend routine colonoscopies for middle-aged and older adults to screen for cancer, the Cleveland Clinic shared.
Schumer Showed Off Her Weight Loss This Weekend
In recent years, Schumer has gotten lots of press for her weight loss transformation, including her use of GLP-1 medications like Wegovy and Mounjaro. Schumer has previously spoken out on social media about why she decided to lose weight. In a now-deleted Instagram reel, she said she did so to "survive" Cushing syndrome, a condition caused by too much of the hormone cortisol in the body, according to the Cleveland Clinic.
"I didn't lose 30 lbs, I lost 50," Schumer explained. "Sorry for whatever feeling it's giving you that I lost that weight." She went on to say that she's now able to play tag with her son, Gene.
In a new photo this weekend, Schumer showed off her new look in a flowing blue dress.
What Has Amy Schumer Said About Using Weight Loss Medications?
One thing fans can always expect from Schumer is honesty. The actress and comedian has spoken candidly with the press about her health. Back in 2023, she appeared on Watch What Happens Live with Andy Cohen and revealed that while she tried using Wegovy several years ago, the side effects were horrific, and she became devastatingly ill as a result. Schumer told Cohen the drug made her "so sick" that she couldn't even play with her son and had to ditch the medication.
"Like, a year ago, I tried it. I was one of those people that felt so sick and couldn't play with my son. I was so skinny, and he's throwing a ball at me and [I couldn't]," she shared.
More recently, Schumer said she's been having a "really good experience" with a different drug called Mounjaro.
"My symptoms of being in perimenopause have disappeared. My hair is fuller, my skin is better, I have more energy. I want to ‘get down' more, if you know what I mean," Schumer shared in a video taken while sitting in her car. "I'm talking about sex."
Copyright 2026 The Arena Group, Inc. All Rights Reserved
This story was originally published May 18, 2026 at 7:49 AM.